Safety of the Cell-Penetrating Peptide Penetratin as an Oral Absorption Enhancer
نویسندگان
چکیده
منابع مشابه
Safety of the cell-penetrating peptide penetratin as an oral absorption enhancer.
Novel delivery technology using cell-penetrating peptides (CPPs) have recently shown their potential and are emerging as promising candidates for an oral protein and peptide delivery systems. As with for the development of any absorption enhancer that is meant to function across an epithelial layer covering a surface highly exposed to pathogens such as the intestines, concern arises about the s...
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Delivery across the cell membrane is of critical importance for the development of therapeutics targeting intracellular proteins. The use of cell-penetrating peptides (CPPs), such as Penetratin (P16), has facilitated the delivery of otherwise cell-impermeable molecules allowing them to carry out their biological function. A truncated form of Penetratin (RRMKWKK) has been previously described as...
متن کاملEffect of cell-penetrating peptide-coated nanostructured lipid carriers on the oral absorption of tripterine
PURPOSE To develop nanostructured-lipid carriers (NLCs) coated with cell-penetrating peptides (CPP) for improving the oral bioavailability of tripterine. METHODS We prepared CPP-coated tripterine-loaded NLCs (CT-NLCs) by using a solvent evaporation method, and determined their physical properties. In vitro drug release was determined by using a dialysis bag diffusion technique, and intestinal...
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BACKGROUND Penetratin is a protein transduction domain derived from the homeoprotein Antennapedia. Thereby it is currently used as a cell penetrating peptide to introduce diverse molecules into eukaryotic cells, and it could also be involved in the cellular export of transcription factors. Moreover, it has been shown that it is able to act as an antimicrobial agent. The mechanisms involved in a...
متن کاملIn vitro and in vivo nuclear factor-kappaB inhibitory effects of the cell-penetrating penetratin peptide.
Penetratin is a cationic cell-penetrating peptide that has been frequently used for the intracellular delivery of polar bioactive compounds. Recent studies have just revealed the major role of polyanionic membrane proteoglycans and cholesterol-enriched lipid rafts in the uptake of the peptide. Both proteoglycans and lipid-rafts influence inflammatory processes by binding a wide array of proinfl...
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ژورنال
عنوان ژورنال: Biological ^|^ Pharmaceutical Bulletin
سال: 2015
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.b14-00517